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Special Neuroscience Research Program at Hunter College |
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Research Laboratory cyclic AMP modulation of axonal regeneration following spinal cord injury CNS Regeneration: Basic Science and Clinical Advances (2008) Academic Press BDNF ACTIVATES CAMKIV AND PKA IN PARALLEL TO BLOCK MAG-MEDIATED INHIBITION OF NEURITE OUTGROWTH Mol. Cell. Neurosci. 2008, 38, 110-116. The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury Experimental Neurology 2008, 209, 321-332 The inhibition site on myelin-associated glycoprotein is within Ig-domain 5 and is distinct from the sialic acid binding site J Neurosci. 2007, 27, 9146-9154
Therapeutic approaches to promoting axonal regeneration in the adult
Mammalian spinal cord Myelin-associated inhibitory signaling and strategies to overcome inhibition J. Cerebr. Blood Flow & Metabol. 2006, 1-12 Recapitulate development to promote axonal regeneration: good or bad approach? Phil. Trans. R. Soc. B. 2006, 361, 1565–1574 The Cytokine Interleukin-6 Is Sufficient But Not Necessary to Mimic the Peripheral Conditioning Lesion Effect on Axonal Growth J. Neurosci. 2006, May 17; 26(20):5565–5573 MAG Induces Regulated Intramembrane Proteolysis of the p75 Neurotrophin Receptor to Inhibit Neurite Outgrowth Neuron. 2005 Jun 16;46(6):849-55 Overcoming inhibitors in myelin to promote axonal regeneration J Neurol Sci. 2005 Jun 15;233(1-2):43-7 Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo Neuron. 2004 Nov 18;44(4):609-21 The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8786-90 A role for cAMP in regeneration of the adult mammalian CNS Journal of Anatomy 2004 Jan; 204:49-55 Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase. J Neurosci. 2003 Dec 17;23(37):11770-7. MYELIN-ASSOCIATED INHIBITORS OF AXONAL REGENERATION IN THE ADULT MAMMALIAN CNS Nat Rev Neurosci. 2003 Sep;4(9):703-13. New Roles for old proteins in adult CNS axonal regeneration. Journal: Curr Opin Neurobiol. 2003 Feb;13(1):133-9. A role for cAMP in regeneration during development and after injury. Journal: Prog Brain Res. 2002;137:381-7. Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth by MAG and myelin in vitro. Neuron. 2002 Aug 15;35(4):711-9. Myelin-Associated Glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron. 2002 Jul 18;35(2):283-90. Spinal axon regeneration induced by elevation of cAMP. Neuron 34: 895-903. Neuronal cAMP controls the developmental loss in ability of axons to regenerate. J Neurosci. 2001 Jul 1;21(13):4731-9. Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron 1999; 22:89-101
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